SS-31
Purity: 99.74%
Batch #: SS3130-001
Verified Potency: 35.55mg
$175.00
SS-31 is a mitochondria-targeting tetrapeptide studied for its role in cellular energy and oxidative stress research.
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Disclaimer
For Research Use Only. Not for human consumption or therapeutic treatment.
About SS-31
SS-31 (Elamipretide) is a small, aromatic tetrapeptide designed to selectively bind cardiolipin in the inner mitochondrial membrane. This interaction supports mitochondrial structure and may reduce reactive oxygen species formation in research models. It is widely used in studies involving mitochondrial dysfunction, bioenergetics, metabolic stress, and cellular resilience. Researchers value SS-31 for its ability to cross cell membranes efficiently and localize directly to mitochondrial compartments.
Product Specifications
SS-31 Lyophilized Powder in 3ml vial
Application
Mitochondrial function and oxidative stress research
Appearance
Solid, white powder in 3mL glass ampule
Chemical Formula
C25H35N9O5
CAS number
127463-38-5
Molecular Weight
~517.6 g/mol
FAQs
What is SS-31 peptide?
SS-31, also known as elamipretide or Bendavia, is a synthetic tetrapeptide with the sequence D-Arg-dimethylTyr-Lys-Phe-NH2. It is a member of the Szeto-Schiller peptide family, named after its developers Hazel Szeto and Peter Bhatt Schiller. SS-31 is a mitochondria-targeted peptide that selectively concentrates in the inner mitochondrial membrane due to its alternating aromatic-cationic amino acid motif, independent of mitochondrial membrane potential.
How does SS-31 target mitochondria?
SS-31 selectively binds to cardiolipin, a phospholipid found exclusively in the inner mitochondrial membrane. Cardiolipin is essential for the structural organization of electron transport chain complexes and for cytochrome c anchoring. By stabilizing cardiolipin-protein interactions, SS-31 improves electron transfer efficiency, reduces electron leak, and lowers mitochondrial reactive oxygen species production. This mechanism is distinct from conventional antioxidants that scavenge free radicals after they are produced.
What is SS-31 researched for?
SS-31 is studied in models of mitochondrial dysfunction, ischemia-reperfusion injury, heart failure, and age-related skeletal muscle decline. Published research reports that SS-31 improves mitochondrial respiration, reduces oxidative damage to mitochondrial membranes, and preserves ATP production under conditions of metabolic stress. It has advanced into clinical trials for conditions including primary mitochondrial myopathy (Barth syndrome) and heart failure with preserved ejection fraction.
Has SS-31 been tested in aging research models?
Yes. Research in aged mice shows that SS-31 treatment reverses age-related declines in mitochondrial function, improves skeletal muscle energetics, and increases exercise tolerance. A study in Cell Reports demonstrated that SS-31 treatment in old mice restored mitochondrial proteostasis and improved hydrogen peroxide emission rates in cardiac mitochondria. These findings position SS-31 as a studied compound in the intersection of mitochondrial biology and aging research.
Can I buy SS-31 peptide for research?
Limitless Peptides sells SS-31 as a lyophilized powder in a sealed 3mL glass ampule. The product is Janoshik verified for identity, potency, and purity. SS-31 is sold for research use only and is not approved for human consumption. The product page includes the manufacturer's certificate of analysis and a link to the independent Janoshik verification report.
