5-Amino-1MQ
5-Amino-1MQ is a small molecule compound investigated for its selective inhibition of NNMT enzyme activity and its influence on cellular metabolism and mitochondrial function.
About 5-Amino-1MQ
~159.2 g/mol
FAQs
5-Amino-1MQ, or 5-amino-1-methylquinolinium, is a small molecule inhibitor of nicotinamide N-methyltransferase, an enzyme that methylates nicotinamide and consumes S-adenosyl methionine in the process. NNMT is expressed in adipose tissue, liver, and skeletal muscle. 5-Amino-1MQ is not a peptide but a quinolinium compound with a molecular weight of approximately 173 g/mol. It is studied for its effects on intracellular NAD+ levels and metabolic regulation.
5-Amino-1MQ inhibits NNMT enzymatic activity, which reduces the methylation and clearance of nicotinamide. Since nicotinamide is a precursor in the NAD+ salvage pathway, NNMT inhibition allows more nicotinamide to be recycled back into NAD+ via nicotinamide phosphoribosyltransferase. Research published in Biochemical Pharmacology describes this mechanism as a way to increase intracellular NAD+ concentrations and shift the S-adenosyl methionine to S-adenosyl homocysteine ratio.
Yes. Research in diet-induced obesity models shows that NNMT inhibition by 5-Amino-1MQ reduces body weight, decreases adipocyte size, and lowers total cholesterol without affecting food intake. These findings are published in studies examining the role of NNMT overexpression in white adipose tissue expansion and its connection to metabolic dysfunction. NNMT is overexpressed in adipose tissue of obese subjects, making it a studied target for metabolic research.
NNMT consumes nicotinamide by methylating it to N1-methylnicotinamide, effectively removing a key substrate from the NAD+ salvage pathway. Inhibiting NNMT with 5-Amino-1MQ preserves the nicotinamide pool, allowing greater flux through NAMPT and into NAD+ biosynthesis. This mechanism connects NNMT inhibition to increased sirtuin activity, improved mitochondrial function, and enhanced cellular energy metabolism in experimental models.
Limitless Peptides sells 5-Amino-1MQ as a lyophilized powder in a sealed 3mL glass ampule. The product is Janoshik verified for identity, potency, and purity. 5-Amino-1MQ is sold for research use only and is not approved for human consumption. The product page includes the manufacturer's certificate of analysis and a link to the independent Janoshik verification report.
