Ipamorelin
Purity: 99.4%
Batch #: IPA10-001
Verified Potency: 10.82mg
$80.00
Ipamorelin is a selective pentapeptide used in research focused on growth hormone secretion pathways.
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Disclaimer
For Research Use Only. Not for human consumption or therapeutic treatment.
About Ipamorelin
Ipamorelin is a highly selective growth hormone secretagogue that binds to the ghrelin receptor (GHSR-1a). Research frequently examines its ability to stimulate pulsatile GH release without significantly influencing cortisol, prolactin, or ACTH pathways. Its clean selectivity profile makes it useful for models studying appetite signaling, metabolic balance, and pituitary function. Ipamorelin is widely used due to its consistent receptor specificity and minimal off-target interaction.
Product Specifications
Ipamorelin Lyophilized Powder in 3ml vial
Application
Growth hormone and ghrelin pathway research
Appearance
Solid, white powder in 3mL glass ampule
Chemical Formula
C38H49N9O5
CAS number
170851-70-4
Molecular Weight
~711.9 g/mol
FAQs
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2. It was developed by Novo Nordisk and is one of the most selective ghrelin receptor (GHS-R1a) agonists studied for growth hormone release. Ipamorelin stimulates pulsatile growth hormone secretion from anterior pituitary somatotrophs without producing the appetite stimulation, cortisol elevation, or prolactin release associated with less selective growth hormone secretagogues.
Why is Ipamorelin considered selective among GHS-R1a agonists?
Ipamorelin stimulates growth hormone release at doses that do not significantly increase cortisol, prolactin, or ACTH levels. Research published in the European Journal of Endocrinology demonstrated this selectivity in both animal and human studies. By comparison, GHRP-6 and GHRP-2 elevate cortisol and prolactin at growth hormone-releasing doses. This selectivity makes ipamorelin a preferred tool when researchers need to isolate growth hormone axis effects from confounding endocrine changes.
How does Ipamorelin stimulate growth hormone release?
Ipamorelin binds to GHS-R1a on pituitary somatotroph cells, activating phospholipase C and the inositol trisphosphate signaling cascade. This raises intracellular calcium, which triggers growth hormone vesicle exocytosis. Ipamorelin's growth hormone response is amplified by co-administration with GHRH analogs because the two peptide classes activate separate intracellular signaling pathways that converge on growth hormone secretion.
What is Ipamorelin researched for beyond growth hormone release?
Research on ipamorelin extends to gastrointestinal motility, where studies report that it accelerates gastric emptying and colonic transit time in post-operative ileus models. Published work in the Journal of Surgical Research describes ipamorelin's prokinetic effects in rodent models of bowel surgery, suggesting a mechanism related to ghrelin receptor activation in the enteric nervous system. This application is distinct from its growth hormone-releasing activity.
Can I buy Ipamorelin for research?
Limitless Peptides sells Ipamorelin as a lyophilized powder in a sealed 3mL glass ampule. The product is Janoshik verified for identity, potency, and purity. Ipamorelin is sold for research use only and is not approved for human consumption. The product page includes the manufacturer's certificate of analysis and a link to the independent Janoshik verification report.
