Thymosin Alpha-1
Purity: 99.866%
Batch #: TA110-001
12.17 mg
$130.00
Thymosin Alpha-1 is a synthetic peptide used in research on immune signaling and thymic-derived regulatory pathways.
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Disclaimer
For Research Use Only. Not for human consumption or therapeutic treatment.
About Thymosin Alpha-1
Thymosin Alpha-1 is a 28-amino-acid peptide that originates from the thymosin fraction 5 family. It is widely used in research models exploring immune modulation, T-cell signaling, cytokine communication, and cellular defense environments. Studies often examine its influence on dendritic cell activity and innate immune pathways. Due to its broad involvement in immune regulation, Thymosin Alpha-1 is frequently used in models requiring enhanced understanding of host-defense signaling.
Product Specifications
Thymosin Alpha-1 Lyophilized Powder in 3ml vial
Application
Immune-modulation and thymic-origin pathway research
Appearance
Solid, white powder in 3mL glass ampule
Chemical Formula
C129H215N33O55
CAS number
62304-98-7
Molecular Weight
~3108.3 g/mol
FAQs
What is Thymosin Alpha-1?
Thymosin Alpha-1 is a 28-amino acid peptide originally isolated from thymic tissue by Allan Goldstein in 1977. It is encoded by the prothymosin alpha gene and is processed from a larger precursor protein. Thymosin Alpha-1 has been approved as a pharmaceutical product (marketed as Zadaxin) in over 35 countries for the treatment of hepatitis B and C, and as an immune adjuvant. Its acetylated N-terminus and defined tertiary structure distinguish it from other thymic peptides.
How does Thymosin Alpha-1 modulate immune function?
Thymosin Alpha-1 acts on dendritic cells and T lymphocytes through Toll-like receptor 9 signaling, promoting maturation of dendritic cells and enhancing antigen presentation. It increases the production of interleukin-2, interferon-alpha, and interferon-gamma, while also promoting the differentiation of CD4+ and CD8+ T cells. Published research in the Annals of the New York Academy of Sciences describes these effects across multiple immune cell types in both in vitro and in vivo models.
Is Thymosin Alpha-1 studied in viral infection research?
Yes. Thymosin Alpha-1 has been studied in the context of hepatitis B, hepatitis C, and HIV infection research. Clinical studies report increased viral clearance and seroconversion rates in hepatitis B patients treated with Thymosin Alpha-1 compared to controls. It has also been examined as an adjuvant to influenza vaccination in elderly populations, where it improved antibody titers and T-cell responses in subjects with weakened baseline immunity.
What distinguishes Thymosin Alpha-1 from other thymic peptides?
Thymosin Alpha-1 is a defined single peptide with a known amino acid sequence, which distinguishes it from crude thymic extract preparations like thymosin fraction 5 or thymalin that contain multiple peptide components. Its mechanism of action through Toll-like receptor signaling and dendritic cell maturation is more clearly characterized than those of peptide mixture preparations. Thymosin Alpha-1 is also the only thymic peptide to have received regulatory approval as a pharmaceutical product in multiple countries.
Can I buy Thymosin Alpha-1 for research?
Limitless Peptides sells Thymosin Alpha-1 as a lyophilized powder in a sealed 3mL glass ampule. The product is Janoshik verified for identity, potency, and purity. Thymosin Alpha-1 is sold for research use only and is not approved for human consumption in the United States. The product page includes the manufacturer's certificate of analysis and a link to the independent Janoshik verification report.
