TB-500
Purity: 99.42%
Batch #: TB500-10-601
Verified Potency: 11.97mg
$165.00
TB-500 is a synthetic peptide fragment derived from thymosin beta-4, commonly used in research on cellular migration and structural recovery pathways.
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Disclaimer
For Research Use Only. Not for human consumption or therapeutic treatment.
About TB-500
TB-500 corresponds to the active region of thymosin beta-4 and is frequently used to study actin regulation, cellular mobility, and tissue-level remodeling. Research highlights its involvement in cytoskeletal organization, angiogenesis models, and recovery-related biological pathways. Due to its stable fragment structure, TB-500 is widely applied in studies focused on cellular response under mechanical, metabolic, or structural stress.
Product Specifications
TB-500 Lyophilized Powder in 3ml vial
Application
Cell migration and cytoskeletal regulation research
Appearance
Solid, white powder in 3mL glass ampule
Chemical Formula
C212H350N56O78S
CAS number
77591-33-4
Molecular Weight
~4963.4 g/mol
FAQs
What is TB-500?
TB-500 is a synthetic peptide fragment corresponding to the active region of Thymosin Beta-4, a 43-amino acid protein first isolated from calf thymus. Thymosin Beta-4 is the principal G-actin sequestering peptide in mammalian cells and is found at high concentrations in blood platelets, wound fluid, and most nucleated cell types. TB-500 replicates a 17-amino acid segment of Thymosin Beta-4 that includes the actin-binding domain responsible for promoting cell migration and cytoskeletal organization.
What is TB-500 researched for?
TB-500 is studied for its effects on cell migration, angiogenesis, and anti-inflammatory signaling. Research published in the Annals of the New York Academy of Sciences describes Thymosin Beta-4's role in promoting endothelial cell migration, keratinocyte migration, and cardiac progenitor cell activation following ischemic injury. Additional studies examine its effects on corneal wound healing, hair follicle stem cell activation, and reduction of pro-inflammatory cytokine expression.
How does TB-500 promote cell migration?
TB-500 promotes cell migration by sequestering G-actin monomers and facilitating actin polymerization at the leading edge of migrating cells. This mechanism increases lamellipodia formation and directional cell movement. Research also shows that Thymosin Beta-4 interacts with the actin cytoskeleton to modulate matrix metalloproteinase activity and integrin expression, both of which are required for cells to traverse extracellular matrix during wound repair and tissue remodeling.
Is TB-500 studied in cardiac research?
Yes. Research published in the Proceedings of the National Academy of Sciences and other journals describes Thymosin Beta-4's effects on cardiac function in mouse models of myocardial infarction. Studies report that Thymosin Beta-4 activates epicardium-derived progenitor cells, promotes coronary vasculogenesis, and reduces fibrosis following ischemic injury. These findings are from preclinical models and have not been tested in human clinical trials.
Can I buy TB-500 for research?
Limitless Peptides sells TB-500 as a lyophilized powder in a sealed 3mL glass ampule. The product is Janoshik verified for identity, potency, and purity. TB-500 is sold for research use only and is not approved for human consumption. The product page includes the manufacturer's certificate of analysis and a link to the independent Janoshik verification report.
