NAD+
Batch #: NAD-500-601
Verified Potency: 571mg
$250.00
NAD+ is a critical redox coenzyme studied for its role in cellular energy production, aging, and mitochondrial function.
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Disclaimer
For Research Use Only. Not for human consumption or therapeutic treatment.
About NAD+
NAD+ serves as an essential electron carrier in metabolic pathways including glycolysis, the TCA cycle, and oxidative phosphorylation. Research focuses heavily on its depletion during aging, its role in sirtuin activation, and its importance in DNA repair and mitochondrial efficiency. Because NAD+ levels directly influence cellular energy status and metabolic signaling, it is widely examined in studies related to longevity, metabolic disorders, and bioenergetic stress. NAD+ remains a central molecule in modern metabolic and aging research.
Product Specifications
NAD+ Lyophilized Powder in vial
Application
Cellular energy metabolism and aging research
Appearance
Solid, white powder in glass ampule
Chemical Formula
C21H27N7O14P2
CAS number
53-84-9
Molecular Weight
~663.4 g/mol
FAQs
What is NAD+?
NAD+, or nicotinamide adenine dinucleotide, is a coenzyme present in all living cells. It exists in two forms: the oxidized form NAD+ and the reduced form NADH. NAD+ participates in over 500 enzymatic reactions and serves as a critical electron carrier in mitochondrial oxidative phosphorylation, where it transfers electrons through the electron transport chain to generate ATP. It is also a required substrate for sirtuins, poly-ADP-ribose polymerases, and CD38, which consume NAD+ in their catalytic reactions.
Why is NAD+ studied in aging research?
NAD+ levels decline measurably with age in multiple tissues, including brain, liver, muscle, and adipose tissue. This decline is associated with reduced sirtuin activity, impaired mitochondrial function, and accumulation of DNA damage. Research by Imai and Guarente published in Trends in Cell Biology established the connection between NAD+ depletion, sirtuin dysfunction, and age-related metabolic decline. Restoration of NAD+ levels in aged mouse models has improved mitochondrial function and physical endurance.
What is the role of NAD+ in DNA repair?
NAD+ is consumed as a substrate by poly-ADP-ribose polymerases, which are enzymes activated in response to DNA strand breaks. PARP1 uses NAD+ to synthesize poly-ADP-ribose chains that recruit DNA repair proteins to damaged sites. High levels of DNA damage can deplete intracellular NAD+ pools, creating a competition between PARP-mediated repair and sirtuin-mediated metabolic regulation. This substrate competition is a studied mechanism linking genomic instability to metabolic dysfunction.
How is NAD+ different from NMN and NR?
NAD+ is the active coenzyme itself, while NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are biosynthetic precursors that cells convert into NAD+ through salvage pathway enzymes. NMN is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase, while NR is first phosphorylated to NMN by nicotinamide riboside kinase. Research on these precursors focuses on their ability to raise intracellular NAD+ levels through oral or systemic administration.
Can I buy NAD+ for research?
Limitless Peptides sells NAD+ as a lyophilized powder in a sealed 3mL glass ampule. The product is Janoshik verified for identity, potency, and purity. NAD+ is sold for research use only and is not approved for human consumption. The product page includes the manufacturer's certificate of analysis and a link to the independent Janoshik verification report.
