GHRP-6
Purity: 99.633%
Batch #: GHRP6-10-601
10.07 mg
$65.00
GHRP-6 is a hexapeptide growth hormone secretagogue used in ghrelin-receptor and appetite-signaling research.
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Disclaimer
For Research Use Only. Not for human consumption or therapeutic treatment.
About GHRP-6
GHRP-6 is a synthetic agonist of the ghrelin receptor (GHSR-1a) and is frequently used in studies involving appetite pathways, endocrine signaling, and pulsatile GH release. It exhibits a strong affinity for ghrelin-mediated hunger signaling, making it a useful tool in research on metabolic balance, pituitary responsiveness, and hypothalamic regulation. GHRP-6’s defined mechanism of action allows researchers to study downstream GH-axis activity and associated metabolic interactions.
Product Specifications
GHRP-6 Lyophilized Powder in 3ml vial
Application
Ghrelin receptor and growth hormone secretagogue research
Appearance
Solid, white powder in 3mL glass ampule
Chemical Formula
C46H56N12O6
CAS number
87616-84-0
Molecular Weight
~873.0 g/mol
FAQs
What is GHRP-6?
GHRP-6, or growth hormone-releasing peptide-6, is a synthetic hexapeptide with the sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2. It was first synthesized in the early 1980s by Cyril Bowers as a met-enkephalin analog that specifically stimulates growth hormone release from the anterior pituitary gland. GHRP-6 binds to the growth hormone secretagogue receptor type 1a (GHS-R1a), the same receptor later identified as the target for ghrelin, the endogenous ligand discovered in 1999.
How does GHRP-6 stimulate growth hormone release?
GHRP-6 acts through two pathways. It directly stimulates somatotroph cells in the anterior pituitary via GHS-R1a activation, triggering the inositol trisphosphate and diacylglycerol signaling cascade, which raises intracellular calcium and promotes growth hormone exocytosis. It also acts indirectly through the hypothalamus by stimulating growth hormone-releasing hormone neurons. Research published in the Journal of Clinical Endocrinology and Metabolism confirmed that endogenous GHRH is necessary for most of the growth hormone response to GHRP-6 in humans.
Does GHRP-6 affect appetite in research models?
Yes. GHRP-6 activates the ghrelin receptor, and ghrelin is the endogenous hunger-signaling peptide produced in the stomach lining. Administration of GHRP-6 in animal models stimulates food intake, increases gastric emptying, and activates hypothalamic appetite-regulating centers. This appetite-stimulating property distinguishes GHRP-6 from other growth hormone secretagogues like GHRP-2, which produces a comparatively weaker orexigenic response.
What is the relationship between GHRP-6 and ghrelin?
GHRP-6 is a synthetic agonist of the GHS-R1a receptor, which is the same receptor activated by ghrelin. The discovery of GHRP-6 and related synthetic secretagogues in the 1980s preceded the identification of ghrelin by nearly two decades. Ghrelin was isolated in 1999 as the endogenous ligand of GHS-R1a, a finding made possible in part by earlier research on GHRP-6 receptor binding. Both GHRP-6 and ghrelin stimulate growth hormone secretion and appetite, though they differ in structure and pharmacokinetics.
Can I buy GHRP-6 for research?
Limitless Peptides sells GHRP-6 as a lyophilized powder in a sealed 3mL glass ampule. The product is independently verified by Janoshik for identity, potency, and purity. GHRP-6 is available for laboratory research use only and is not intended for human consumption. The product page includes the certificate of analysis and a link to the Janoshik verification report.
