Semax

Name: Semax
Brand: Limitless Peptides
SKU: SEMAX-10-601
Price: 90.00 USD
Availability: InStock

Purity: 99.130%

Batch #: SEMAX-10-601

Verified Potency: 11.96mg

$90.00

Semax is a synthetic heptapeptide used in research on neuroplasticity, cognitive signaling, and central nervous system (CNS) regulation.

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Disclaimer

For Research Use Only. Not for human consumption or therapeutic treatment.

About Semax

Semax is a peptide analog derived from the adrenocorticotropic hormone (ACTH) fragment (4–10) and is widely used in neuro-model research involving cognitive performance, neurotrophic signaling, and stress-response modulation. Research has explored its influence on brain-derived neurotrophic factor (BDNF) expression, dopaminergic and serotonergic pathways, and mechanisms related to learning, memory consolidation, and attention. Unlike classical stimulants or sedatives, Semax is studied for its role in enhancing cognitive efficiency and neural resilience without direct excitatory or depressant effects. It is frequently employed in experimental models examining neuroprotection, synaptic plasticity, cerebral metabolism, and adaptive CNS communication under stress or cognitive load.

Product Specifications

Semax Lyophilized Powder in 3 mL vial

Application

Neuropeptide, cognitive enhancement, neuroplasticity, and CNS research

Appearance

Solid, white powder in 3 mL glass ampule

Chemical Formula

C37H51N9O10

CAS number

80714-61-0

Molecular Weight

~813.9 g/mol

FAQs

What is Semax peptide?

Semax is a synthetic heptapeptide consisting of the amino acid sequence Met-Glu-His-Phe-Pro-Gly-Pro. It is derived from the first four amino acids of adrenocorticotropic hormone (ACTH 4-7) with an added Pro-Gly-Pro tripeptide extension at the C-terminus that stabilizes the molecule against enzymatic degradation. Semax was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and has been registered as a pharmaceutical product in Russia since 1994.

What is Semax researched for?

Semax is studied for its effects on neurotrophic factor expression, particularly brain-derived neurotrophic factor and nerve growth factor. Published research reports that Semax increases BDNF and NGF mRNA expression in rat hippocampus and cortex. Additional research areas include its effects on cognitive function in animal models of cerebral ischemia, its influence on dopaminergic and serotonergic neurotransmission, and its modulation of immune-related gene expression in brain tissue.

How does Semax differ from ACTH?

Semax retains the ACTH(4-7) fragment that is associated with cognitive and neurotrophic effects but lacks the steroidogenic activity of the full ACTH molecule. The Pro-Gly-Pro C-terminal extension protects the peptide from aminopeptidase cleavage, increasing its stability compared to the native ACTH fragment. Unlike full-length ACTH, Semax does not stimulate cortisol production because it lacks the receptor binding domain required for adrenal steroidogenesis.

Has Semax been studied in cerebral ischemia models?

Yes. Animal studies of focal cerebral ischemia report that Semax administration reduces infarct volume and improves neurological outcome scores. Research published in Doklady Biological Sciences and other Russian-language journals describes changes in gene expression profiles in penumbral brain tissue following Semax treatment, including upregulation of neurotrophic and anti-apoptotic genes and downregulation of inflammatory mediators.

Can I buy Semax peptide for research?

Limitless Peptides sells Semax as a lyophilized powder in a sealed 3mL glass ampule. The product is Janoshik verified for identity, potency, and purity. Semax is sold for research use only and is not approved for human consumption in the United States. The product page includes the manufacturer's certificate of analysis and a link to the independent Janoshik verification report.

Semax

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