VIP
Purity: 99.506%
Batch #: VIP-10-601
11.61 mg
$75.00
VIP is a neuropeptide used in research involving vasodilation, inflammatory signaling, and neuro-immune communication.
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Disclaimer
For Research Use Only. Not for human consumption or therapeutic treatment.
About VIP
Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuropeptide expressed in the central nervous system, gut, and immune tissues. Research frequently examines its roles in vasodilation, smooth-muscle relaxation, cytokine regulation, and circadian-rhythm modulation. VIP’s diverse receptor interactions, particularly with VPAC1 and VPAC2, make it useful for exploring neuro-immune communication and autonomic signaling in complex cellular environments.
Product Specifications
VIP Lyophilized Powder in 3ml vial
Application
Vasodilation, neuro-immune, and inflammatory-pathway research
Appearance
Solid, white powder in 3mL glass ampule
Chemical Formula
C147H238N44O37S
CAS number
16960-16-0
Molecular Weight
~3325.8 g/mol
FAQs
What is VIP peptide?
VIP, or vasoactive intestinal peptide, is a 28-amino acid neuropeptide first isolated from porcine duodenum in 1970. It belongs to the secretin and glucagon hormone superfamily and is widely distributed in the central and peripheral nervous systems, as well as the gastrointestinal tract, heart, lungs, and brain. VIP binds to two G-protein-coupled receptors, VPAC1 and VPAC2, which activate adenylyl cyclase and increase intracellular cyclic AMP concentrations.
What biological functions does VIP regulate?
VIP regulates a range of physiological processes. In the gastrointestinal system, it stimulates water and electrolyte secretion, relaxes smooth muscle in the stomach and gallbladder, and inhibits gastric acid secretion. In the cardiovascular system, research published in Cardiovascular Research shows VIP causes vasodilation and has positive inotropic and chronotropic effects on cardiac muscle. VIP also plays a role in circadian rhythm synchronization within the suprachiasmatic nuclei.
How is VIP studied in immune modulation research?
VIP is studied as a neuroimmune modulator. Published research in F1000Research describes its effects on immune cell regulation, including modulation of inflammatory cytokine profiles, reduction of pro-inflammatory mediators, and regulation of T-cell function. VIP signaling through VPAC receptors on immune cells activates anti-inflammatory cascades involving cyclic AMP and protein kinase A pathways, which are areas of ongoing investigation in autoimmune disease models.
What role does VIP play in circadian rhythm research?
VIP is concentrated in the ventrolateral region of the suprachiasmatic nuclei, which receives retinal input from the retinohypothalamic tract. Research shows VIP synchronizes neuronal firing within the suprachiasmatic nuclei and phase-shifts the circadian rhythm of vasopressin release and neural activity. VIP-deficient mice lose the ability to maintain synchronized circadian oscillations, confirming the peptide's role in the mammalian circadian timekeeping system.
Can I buy VIP peptide for research?
Limitless Peptides sells VIP as a lyophilized powder in a sealed 3mL glass ampule at research grade purity. The product is independently verified by Janoshik for identity and potency. VIP is sold strictly for laboratory research use and is not intended for human consumption. A certificate of analysis and Janoshik verification report are accessible on the product page.
