Kisspeptin

Name: Kisspeptin
Brand: Limitless Peptides
SKU: KISS-10-601
Price: 80.00 USD
Availability: InStock

Purity: 99.510%

Batch #: KISS-10-601

Verified Potency: 12.40mg

$80.00

Kisspeptin is a naturally occurring neuropeptide investigated for its central role in reproductive hormone regulation, fertility pathways, and hypothalamic-pituitary-gonadal axis signaling.

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Disclaimer

For Research Use Only. Not for human consumption or therapeutic treatment.

About Kisspeptin

Kisspeptin is a neuropeptide encoded by the KISS1 gene that serves as a master regulator of gonadotropin-releasing hormone (GnRH) secretion in the hypothalamus. Through its interaction with the GPR54 receptor (KISS1R), kisspeptin orchestrates critical aspects of reproductive biology, including puberty initiation, ovulation timing, and fertility optimization. Research extensively examines its influence on the hypothalamic-pituitary-gonadal axis, exploring how this peptide coordinates hormonal cascades that govern reproductive health. Scientists also investigate kisspeptin's intriguing connections to metabolic-reproductive crosstalk and energy balance. Its pivotal role in neuroendocrine communication makes kisspeptin an essential research tool for understanding fertility pathways, hormonal regulation, and the complex interplay between metabolic status and reproductive function.

Product Specifications

Kisspeptin Lyophilized Powder in 3ml vial

Application

Reproductive hormone and GnRH pathway research

Appearance

Solid, white powder in 3mL glass ampule

Chemical Formula

C63H83N17O14

CAS number

374675-21-5

Molecular Weight

~1302.4 g/mol

FAQs

What is Kisspeptin?

Kisspeptin is a family of peptide fragments encoded by the KISS1 gene, with kisspeptin-54 being the full-length biologically active form. Shorter fragments including kisspeptin-14, kisspeptin-13, and kisspeptin-10 also retain activity at the kisspeptin receptor (KISS1R, formerly GPR54). Kisspeptin was first identified in 1996 as a metastasis suppressor gene product, and its role in reproductive endocrinology was established in 2003 when loss-of-function mutations in KISS1R were linked to hypogonadotropic hypogonadism.

What role does Kisspeptin play in reproductive endocrinology?

Kisspeptin is the most potent known stimulator of gonadotropin-releasing hormone secretion from hypothalamic GnRH neurons. Kisspeptin neurons in the arcuate nucleus and the anteroventral periventricular nucleus form the KNDy (kisspeptin/neurokinin B/dynorphin) neuronal network, which generates the pulsatile GnRH release pattern required for normal luteinizing hormone and follicle-stimulating hormone secretion from the anterior pituitary gland.

Has Kisspeptin been studied in humans?

Yes. Clinical studies have administered kisspeptin-54 to both men and women to evaluate its effects on gonadotropin release. Research published in the Journal of Clinical Investigation demonstrated that a single intravenous bolus of kisspeptin-54 stimulated robust LH and FSH release in healthy men. Studies in women report that kisspeptin responsiveness varies across the menstrual cycle, with the greatest gonadotropin response occurring during the preovulatory phase.

What is the connection between Kisspeptin and puberty?

Kisspeptin signaling is required for the initiation of puberty. Loss-of-function mutations in either the KISS1 gene or its receptor KISS1R cause failure to enter puberty in humans, a condition known as idiopathic hypogonadotropic hypogonadism. Conversely, gain-of-function mutations in KISS1R are associated with precocious puberty. These genetic findings, confirmed in multiple independent families, established kisspeptin as an essential gatekeeper of the pubertal transition.

Can I buy Kisspeptin for research?

Limitless Peptides sells Kisspeptin as a lyophilized powder in a sealed 3mL glass ampule. The product is Janoshik verified for identity, potency, and purity. Kisspeptin is sold for research use only and is not approved for human consumption. The product page includes the manufacturer's certificate of analysis and a link to the independent Janoshik verification report.

Kisspeptin

About Kisspeptin

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