PE-22-28

Name: Oxytocin
Brand: Limitless Peptides
SKU: OXY-10-601
Price: 90.00 USD
Availability: InStock

Purity: 99.811%

Batch #: PE2-10-601

Verified Potency: 11.81mg

$120.00

PE-22-28 is a synthetic peptide studied for its potential anti-inflammatory properties and its influence on immune system modulation and cytokine signaling pathways.

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Disclaimer

For Research Use Only. Not for human consumption or therapeutic treatment.

About PE-22-28

PE-22-28 is a synthetic peptide that has garnered research interest for its potential anti-inflammatory and immunomodulatory characteristics. Scientists investigate its effects on cytokine regulation, inflammatory pathway balance, and immune response optimization in various experimental models. Research explores how PE-22-28 may interact with immune signaling cascades to promote balanced inflammatory responses and support cellular defense mechanisms. Its specific peptide structure allows for targeted receptor interactions, making it a valuable tool for studying precision approaches to inflammation management. PE-22-28 represents an emerging area of peptide research focused on understanding how synthetic peptides can influence the body's natural immune and inflammatory processes.

Product Specifications

PE-22-28 Lyophilized Powder in 3ml vial

Application

Anti-inflammatory and immune modulation research

Appearance

Solid, white powder in 3mL glass ampule

Chemical Formula

C127H204N42O36

CAS number

188807-13-3

Molecular Weight

~2933.3 g/mol

FAQs

What is PE-22-28 peptide?

PE-22-28 is a synthetic heptapeptide derived from the spadin family of peptides, which are themselves derived from the propeptide of sortilin (sort-pro). It acts as an antagonist of the TREK-1 potassium channel, a two-pore-domain potassium channel expressed in the central nervous system. TREK-1 channel blockade has been associated with antidepressant-like effects in rodent behavioral models, making PE-22-28 a studied compound in neuropharmacology research.

What is PE-22-28 researched for?

PE-22-28 is studied for its antidepressant-like effects in animal models, including the forced swim test and tail suspension test in mice. Published research reports that PE-22-28 administration produces behavioral changes consistent with antidepressant activity and increases hippocampal neurogenesis. Additional research examines its effects on brain-derived neurotrophic factor expression and synaptic plasticity in the hippocampus.

How does PE-22-28 relate to TREK-1 channel function?

TREK-1 is a background leak potassium channel that stabilizes neuronal resting membrane potential. Genetic deletion of the TREK-1 gene (KCNK2) in mice produces a depression-resistant phenotype, and TREK-1 knockout mice show increased serotonergic neurotransmission in the dorsal raphe nucleus. PE-22-28 blocks TREK-1 channel conductance, mimicking aspects of the knockout phenotype and providing a pharmacological tool to study this potassium channel's role in mood regulation.

How does PE-22-28 compare to spadin?

Spadin is a 17-amino acid peptide also derived from the sort-pro propeptide that blocks TREK-1. PE-22-28 is a shorter, modified fragment that retains TREK-1 antagonist activity with improved metabolic stability compared to the full spadin sequence. Research published in the British Journal of Pharmacology and Neuropharmacology describes PE-22-28 as having a longer duration of action and comparable efficacy to spadin in behavioral models of depression.

Can I buy PE-22-28 peptide for research?

Limitless Peptides sells PE-22-28 as a lyophilized powder in a sealed 3mL glass ampule. The product is Janoshik verified for identity, potency, and purity. PE-22-28 is sold for research use only and is not approved for human consumption. The product page includes the manufacturer's certificate of analysis and a link to the independent Janoshik verification report.

PE-22-28

About PE-22-28

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