KPV
Purity: 99.672%
Batch #: KPV-10-601
11.72 mg
$99.00
KPV is a tripeptide fragment of α-MSH used in inflammation and immune-pathway research.
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Disclaimer
For Research Use Only. Not for human consumption or therapeutic treatment.
About KPV
KPV contains the amino-acid sequence Lys-Pro-Val and represents the C-terminal end of alpha-melanocyte-stimulating hormone. It is frequently studied for its interaction with melanocortin receptors, especially MC1R, in models involving inflammation balance, epithelial barrier environments, and cytokine signaling. Due to its stability and small molecular structure, KPV is a widely used tool for investigating immune response modulation and inflammation-related pathways.
Product Specifications
KPV Lyophilized Powder in 3ml vial
Application
Inflammation and immune-signaling pathway research
Appearance
Solid, white powder in 3mL glass ampule
Chemical Formula
C19H30N4O4
CAS number
88229-20-3
Molecular Weight
~378.5 g/mol
FAQs
What is KPV peptide?
KPV is a tripeptide consisting of the amino acids lysine, proline, and valine. It is derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone, specifically positions 11 through 13 of the full alpha-MSH molecule. Despite lacking the melanocortin receptor binding domain of the parent peptide, KPV retains anti-inflammatory activity through mechanisms that are independent of melanocortin receptor signaling.
What is KPV researched for?
KPV is studied for its anti-inflammatory effects in cellular and animal models. Published research reports that KPV inhibits nuclear factor kappa-B activation and reduces the expression of pro-inflammatory cytokines including interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha. Studies in murine colitis models show that KPV reduces intestinal inflammation and tissue damage when administered orally, suggesting an interaction with intestinal epithelial cells.
How does KPV reduce inflammation without melanocortin receptor binding?
KPV enters cells and directly interacts with intracellular inflammatory signaling pathways rather than binding to melanocortin receptors on the cell surface. Research shows that KPV inhibits the nuclear translocation of nuclear factor kappa-B by preventing the phosphorylation and degradation of its inhibitor, IkB-alpha. This intracellular mechanism allows KPV to suppress inflammatory gene transcription even in cell types that do not express melanocortin receptors.
Is KPV studied in gastrointestinal research?
Yes. Research in murine models of inflammatory bowel disease shows that oral administration of KPV reduces colonic inflammation, decreases mucosal damage scores, and lowers pro-inflammatory cytokine levels in intestinal tissue. Studies published in the Journal of Biological Chemistry and PLoS ONE describe KPV's transepithelial transport across intestinal epithelial monolayers and its uptake by colonocytes via the oligopeptide transporter PepT1.
Can I buy KPV peptide for research?
Limitless Peptides sells KPV as a lyophilized powder in a sealed 3mL glass ampule. The product is Janoshik verified for identity, potency, and purity. KPV is sold for research use only and is not approved for human consumption. The product page includes the manufacturer's certificate of analysis and a link to the independent Janoshik verification report.
