MOTS-c
Purity: 99.07%
Batch #: MOTSC10-001
Verified Potency: 11.84mg
$110.00
MOTS-c is a mitochondrial-derived peptide studied for its metabolic regulatory effects and AMPK-related pathways.
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Disclaimer
For Research Use Only. Not for human consumption or therapeutic treatment.
About MOTS-c
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene. Research commonly investigates its ability to activate AMPK, support glucose utilization, and maintain metabolic balance under cellular stress. Because it is derived from mitochondrial DNA, MOTS-c has garnered significant interest in aging models, exercise physiology research, and studies involving metabolic resilience. Its unique origin makes it a key tool for exploring mito-nuclear communication pathways.
Product Specifications
MOTS-c Lyophilized Powder in 3ml vial
Application
AMPK activation and metabolic regulation research
Appearance
Solid, white powder in 3mL glass ampule
Chemical Formula
C64H107N17O20
CAS number
148686-78-8
Molecular Weight
~1479.6 g/mol
FAQs
What is MOTS-c peptide?
MOTS-c is a 16-amino acid peptide encoded in the 12S rRNA region of the mitochondrial genome. It was first described by Lee et al. in 2015 and is classified as a mitochondrial-derived peptide. MOTS-c is detected in plasma and in multiple tissues including skeletal muscle, brain, and liver. It acts as a systemic hormone and is one of several bioactive peptides encoded by small open reading frames within mitochondrial DNA.
Why is MOTS-c called an exercise mimetic?
MOTS-c is described as an exercise mimetic because its administration in rodent models produces metabolic effects similar to physical exercise, including increased glucose utilization, fatty acid oxidation, and AMPK activation. A 2021 study in Nature Communications showed that skeletal muscle MOTS-c levels increased nearly 12-fold during acute exercise in healthy young men, while circulating plasma levels rose approximately 50%. These findings suggest the peptide is endogenously induced by physical activity and mediates metabolic adaptations.
What metabolic pathways does MOTS-c affect?
MOTS-c activates AMP-activated protein kinase and increases endogenous AICAR levels, which are upstream regulators of metabolic homeostasis. Research published in Physiological Reports showed MOTS-c reduced sphingolipid metabolism, monoacylglycerol metabolism, and dicarboxylate metabolism in diet-induced obese mice, all of which are pathways upregulated in obesity and type 2 diabetes models. MOTS-c also improved insulin sensitivity and promoted beta-oxidation to reduce hepatic fat accumulation.
Does MOTS-c affect muscle biology in research?
Yes. Research published in the American Journal of Physiology demonstrated that MOTS-c reduces myostatin expression in diet-induced obese mice through FOXO1 inhibition via AKT phosphorylation. MOTS-c plasma levels were inversely correlated with myostatin levels in human subjects. In aged mouse models, late-life MOTS-c treatment (initiated at 23.5 months) increased physical capacity and improved performance on treadmill and rotarod tests compared to untreated controls.
Can I buy MOTS-c peptide for research?
Limitless Peptides sells MOTS-c as a lyophilized powder in a sealed 3mL glass ampule. The product is independently verified by Janoshik for identity, potency, and purity. MOTS-c is available for laboratory research use only and is not intended for human consumption. The product page includes the certificate of analysis and a link to the Janoshik verification report.
